TY - JOUR
T1 - Association between periodontal disease and the risk of COVID-19 complications and mortality
T2 - A systematic review
AU - Espinoza-Espinoza, Daniel
AU - Dulanto-Vargas, Julissa
AU - Cáceres-Latorre, Oswaldo
AU - Lamas-Castillo, Fiorella
AU - Flores-Mir, Carlos
AU - Cervantes-Ganoza, Luis
AU - López-Gurreonero, Carlos
AU - Ladera-Castañeda, Marysela
AU - Cayo-Rojas, César
N1 - Publisher Copyright:
© 2021 Wolters Kluwer (UK) Ltd.. All rights reserved.
PY - 2021/11/1
Y1 - 2021/11/1
N2 - Aim: The COVID-19 pandemic has strained the world's healthcare systems. Studies have identified how the COVID-19 infections are linked to several co-morbidities such as hypertension, diabetes, cardiovascular disease, renal and pulmonary disease. It is known that periodontal disease (PD) shares the same risk factors. Moreover, both diseases are characterized by an exaggerated immune response. The aim of the study was to investigate the available evidence of a potential association between PD and the risk of COVID-19 complications and mortality. Materials and Methods: MEDLINE/PubMed, EMBASE, Scopus, and ProQuest were searched. Studies that assess the association between PD and the risk of COVID-19 complications and mortality were eligible for inclusion. Two independent reviewers performed the selection of articles and data extraction. The New Castle Ottawa Scale was used to assess the quality of the selected studies, and the GRADE system was used to evaluate the level of confidence to support the conclusions. Results: Only two studies met the eligibility criteria. One study had a low risk of bias, whereas the other had a high risk of bias. Conclusion: The level of confidence in the available evidence is very low. A close association between periodontitis and the risk of COVID-19 complications and mortality can neither be supported nor refuted.
AB - Aim: The COVID-19 pandemic has strained the world's healthcare systems. Studies have identified how the COVID-19 infections are linked to several co-morbidities such as hypertension, diabetes, cardiovascular disease, renal and pulmonary disease. It is known that periodontal disease (PD) shares the same risk factors. Moreover, both diseases are characterized by an exaggerated immune response. The aim of the study was to investigate the available evidence of a potential association between PD and the risk of COVID-19 complications and mortality. Materials and Methods: MEDLINE/PubMed, EMBASE, Scopus, and ProQuest were searched. Studies that assess the association between PD and the risk of COVID-19 complications and mortality were eligible for inclusion. Two independent reviewers performed the selection of articles and data extraction. The New Castle Ottawa Scale was used to assess the quality of the selected studies, and the GRADE system was used to evaluate the level of confidence to support the conclusions. Results: Only two studies met the eligibility criteria. One study had a low risk of bias, whereas the other had a high risk of bias. Conclusion: The level of confidence in the available evidence is very low. A close association between periodontitis and the risk of COVID-19 complications and mortality can neither be supported nor refuted.
KW - COVID-19
KW - Complications
KW - SARS-COV-2
KW - mortality
KW - periodontitis
UR - http://www.scopus.com/inward/record.url?scp=85121005506&partnerID=8YFLogxK
U2 - 10.4103/jispcd.JISPCD_189_21
DO - 10.4103/jispcd.JISPCD_189_21
M3 - Review article
AN - SCOPUS:85121005506
SN - 2231-0762
VL - 11
SP - 626
EP - 638
JO - Journal of International Society of Preventive and Community Dentistry
JF - Journal of International Society of Preventive and Community Dentistry
IS - 6
ER -
